These European Resuscitation Council (ERC) Guidelines 2025 on Newborn Life Support are based on the International Liaison Committee on Resuscitation (ILCOR) Consensus on Science with Treatment Recommendations (CoSTRs) for Neonatal Life Support. These Guidelines present a logical approach to resuscitation and support of transition to extra-uterine life, for both preterm and term newborn infants. These Guidelines include factors before birth, training and education, thermal control, management of the umbilical cord after birth, initial assessment, airway, breathing and circulation assessment and interventions, emergency vascular access, low resource and out of hospital settings, communication with parents, and considerations on withholding and discontinuing life sustaining treatments. Life support guidelines for older infants and children are covered in the ERC Guidelines 2025 Paediatric Life Support.