Environmental dimensions of antibiotic resistance: assessment of basic science gaps

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Kornelia Smalla - , Julius Kühn Institute - Federal Research Centre for Cultivated Plants (Autor:in)
  • Kimberly Cook - , United States Department of Agriculture (Autor:in)
  • Steven P. Djordjevic - , University of Technology Sydney (Autor:in)
  • Uli Klümper - , ESI & CEC, University of Exeter (Autor:in)
  • Michael Gillings - , Macquarie University (Autor:in)

Abstract

Antibiotic resistance is one of the major problems facing medical practice in the 21st century. Historical approaches to managing antibiotic resistance have often focused on individual patients, specific pathogens and particular resistance phenotypes. However, it is increasingly recognized that antibiotic resistance is a complex ecological and evolutionary problem. As such, understanding the dynamics of antibiotic resistance requires integration of data on the diverse mobile genetic elements often associated with antibiotic resistance genes, and their dissemination by various mechanisms of horizontal gene transfer between bacterial cells and environments. Most important is understanding the fate and effects of antibiotics at sub-inhibitory concentrations, and co-selection. This opinion paper identifies key knowledge gaps in our understanding of resistance phenomena, and outlines research needs that should be addressed to help us manage resistance into the future.

Details

OriginalspracheEnglisch
FachzeitschriftFEMS Microbiology Ecology
Jahrgang94
Ausgabenummer12
PublikationsstatusVeröffentlicht - 1 Dez. 2018
Peer-Review-StatusJa
Extern publiziertJa

Externe IDs

PubMed 30277517
ORCID /0000-0002-4169-6548/work/142247367