Challenges in integrating AI into operational socio-technical systems due to human factors, workflows, and needs. Human-centred implementation is critical to overcoming resistance and ensuring successful adoption. Enhancing technology acceptance in AI systems within socio-technical frameworks by emphasizing Human-Centred Design (HCD). Three levels of human inclusion are critical—technology, organization, and mutual participation—each requiring specific methods and approaches for effective AI implementation. Translating academic research into practical, business-oriented applications while aligning with sustainability goals is essential. Adaptation to practical cases is necessary. A human-centred approach is crucial for technology acceptance, and this approach should be tailored to the context of the socio-technical system.