Enhancement of antimicrobial activity by co-administration of poly(propylene imine) dendrimers and nadifloxacin

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Aleksandra Felczak - , Lodz University of Technology (Autor:in)
  • Katarzyna Zawadzka - , Lodz University of Technology (Autor:in)
  • Natalia Wronska - , Lodz University of Technology (Autor:in)
  • Anna Janaszewska - , Lodz University of Technology (Autor:in)
  • Barbara Klajnert - , Lodz University of Technology (Autor:in)
  • Maria Bryszewska - , Lodz University of Technology (Autor:in)
  • Dietmar Appelhans - , Leibniz-Institut für Polymerforschung Dresden (Autor:in)
  • Brigitte Voit - , Leibniz-Institut für Polymerforschung Dresden (Autor:in)
  • Katarzyna Lisowska - , Lodz University of Technology (Autor:in)

Abstract

Despite the studies of dendrimers for biomedical application, the antibacterial activity of dendrimers has not been extensively explored. In the presented study we evaluate the antimicrobial activity of poly(propylene imine) dendrimers (PPI-G4) and their derivatives modified with maltose (PPI-25% mG4) in combination with nadifloxacin against Gram-negative bacteria Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 15442 and Proteus hauseri ATCC 13315. Cytotoxicity of all studied dendrimers and nadifloxacin was investigated in a Chinese hamster fibroblast cell line (B14), a human liver hepatocellular carcinoma cell line (HepG2), a mouse neuroblastoma cell line (N2a) and a rat liver cell line (BRL-3A). The obtained results indicate that co-administration of nadifloxacin and studied dendrimers enhances the antimicrobial activity of the antibiotic against Gram-negative bacteria, at concentrations that are at the same time harmless to the eukaryotic cell lines. Moreover, the contribution of dendrimers allows using lower doses of the antibiotic.

Details

OriginalspracheEnglisch
Seiten (von - bis)4156-4162
Seitenumfang7
FachzeitschriftNew journal of chemistry
Jahrgang37
Ausgabenummer12
PublikationsstatusVeröffentlicht - 2013
Peer-Review-StatusJa
Extern publiziertJa

Externe IDs

Scopus 84887851289
ORCID /0000-0002-4531-691X/work/148607887

Schlagworte

Schlagwörter

  • Polyamidoamine pamam dendrimers, Biological-properties, Infections, Carriers, Drug