Aims: The previous recommendations of the German Centre for Addiction Issues (DHS) how to deal with alcohol were based on low-risk drinking limits. The aim of this statement was to update this recommendation. Methods: A narrative review of the current literature on the relationship between alcohol consumption and the development of morbidity and mortality was carried out by a sub-working group of the Scientific Board of Trustees of the DHS. The summary of the evidence and the recommendations derived from it were agreed upon by the entire Board of Trustees and adopted by the DHS Board. Results: A positive relation between alcohol consumption and health, as found in earlier studies, is due to methodological shortcomings. It cannot be concluded from the evidence that alcohol has a health-promoting effect. In addition, available data reveal a linear relationship between alcohol consumption and the development of diseases and premature death. The linear associations between the amount of alcohol consumed and the probability of falling ill or dying apply to common diseases in both men and women. Conclusion: Recommendations based on low-risk drinking quantities can no longer be upheld. Instead, it is recommended to reduce alcohol consumption - regardless of the amount of alcohol drunk. For physical health it is best not to drink alcohol at all.