Effect of periodontal therapy on adipokine biomarkers in overweight

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Johannes Matern - , Westfälische Wilhelms-Universität Münster (Autor:in)
  • Raphael Koch - , Westfälische Wilhelms-Universität Münster (Autor:in)
  • Astrid Petersmann - , Ernst-Moritz-Arndt-Universität Greifswald (Autor:in)
  • Thomas Kocher - , Ernst-Moritz-Arndt-Universität Greifswald (Autor:in)
  • Peter Eickholz - , Universitätsklinikum Frankfurt (Autor:in)
  • Katrin Lorenz - , Poliklinik für Parodontologie (Autor:in)
  • Ti Sun Kim - , Universität Heidelberg (Autor:in)
  • Jörg Meyle - , Justus-Liebig-Universität Gießen (Autor:in)
  • Doğan Kaner - , Charité – Universitätsmedizin Berlin, Universität Witten/Herdecke (Autor:in)
  • Ulrich Schlagenhauf - , Julius-Maximilians-Universität Würzburg (Autor:in)
  • Martina Gravemeier - , Westfälische Wilhelms-Universität Münster (Autor:in)
  • Inga Harks - , Westfälische Wilhelms-Universität Münster (Autor:in)
  • Benjamin Ehmke - , Westfälische Wilhelms-Universität Münster (Autor:in)

Abstract

Aim: The aim of this study was to evaluate the effect of non-surgical periodontal therapy on circulating levels of the systemic inflammation-associated biomarkers orosomucoid (ORM), high-sensitivity C-reactive protein (hsCRP), chemerin, and retinol-binding protein 4 (RBP4) in overweight or normal-weight patients with periodontitis at 27.5 months after therapy.

Materials and methods: This exploratory subanalysis includes patients from the ABPARO-trial (ClinicalTrials.gov NCT00707369). The per-protocol collective provided untreated periodontitis patients with high (≥28 kg/m2 ) or moderate (21-24 kg/m2 ) BMI. Out of the per-protocol collective, 80 patients were randomly selected and stratified for BMI group, sex, and treatment group (antibiotics/placebo), resulting in 40 overweight and normal-weight patients. Patients received non-surgical periodontal therapy and maintenance at 3-month intervals. Plasma samples from baseline and 27.5 months following initial treatment were used to measure the concentrations of ORM, hsCRP, chemerin, and RBP4.

Results: At the 27.5-month examination, ORM and hsCRP decreased noticeably in the overweight group (ORM: p = .001, hsCRP: p = .004) and normal-weight patients (ORM: p = .007, hsCRP: p < .001). Chemerin decreased in the overweight group (p = .048), and RBP4 concentrations remained stable.

Conclusion: Non-surgical periodontal therapy reduced systemically elevated inflammation-associated biomarkers in periodontitis patients. These improvements were more pronounced in overweight patients than in normal-weight patients.

Details

OriginalspracheEnglisch
Seiten (von - bis)842-850
Seitenumfang9
FachzeitschriftJournal of clinical periodontology
Jahrgang47
Ausgabenummer7
PublikationsstatusVeröffentlicht - 1 Juli 2020
Peer-Review-StatusJa

Externe IDs

PubMed 32248552
ORCID /0000-0002-0228-6140/work/146167270

Schlagworte

ASJC Scopus Sachgebiete

Schlagwörter

  • chemerin, orosomucoid, overweight, periodontitis, retinol-binding protein 4