This study examines the economic potential of 12 native Angolan plant species. In October/November 2016, field trips and market analyses were conducted in the province of Cuanza Norte and Luanda. The data were supplemented with global market information obtained in 2017. We conducted interviews in 48 different locations in Cuanza Norte (105 informants), complemented by 96 merchants. The informant consensus factor was calculated for 786 use reports from Cuanza Norte, classified into five different use categories by applying a scoring system. Adapting and comparing the cultural with the economic value of each species, five plant species proved to be profitable for the province (Adansonia digitata, Aframomum melegueta, Cochlospermum angolense, Cola acuminata, Xylopia aethiopica). These species are promising for a more detailed economic and ecological analysis due to their high local importance and national and/or international demand. Additional research is needed to acquire detailed information regarding plant distribution and numbers, specific growth conditions, sustainable harvesting methods, and processing of the raw plant material.