Diffusion-weighted MRI for initial staging in Hodgkin`s lymphoma: comparison with FDG PET
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Beitragende
Abstract
PURPOSE: To evaluate the use of diffusion-weighted MRI (DWI) for initial staging of Hodgkin`s lymphoma and compare it to FDG PET.
METHODS: Forty-one patients with Hodgkin`s lymphoma (14 f, 27 m, median age 39 y) were included in this retrospective study. All patients underwent FDG PET/MR for initial staging, including DWI. The Lugano classification was used to describe disease extent. A combination of follow-up imaging and histopathology served as the reference standard. Method agreement was assessed using weighted kappa (κ). The accuracy of the imaging methods was evaluated using ROC curve analysis.
RESULTS: Regarding the Lugano stage, DWI and FDG PET had identical results in 34/41 cases (κ = 0.77). Sensitivity and specificity for nodal involvement was 89.9% and 93.8% for DWI, and 93.8% and 86.9% for FDG PET, respectively. In regard to extranodal involvement, sensitivity and specificity were 88.5% and 99.3% for DWI and 92.3% and 92.7% for FDG PET. The accuracy of both methods for nodal (p = 0.06) and extranodal involvement (p = 0.66) did not differ significantly.
CONCLUSION: Despite high sensitivity and specificity, DWI in free breathing cannot be currently recommended as an alternative to FDG PET in initial staging of Hodgkin`s lymphoma due to substantial differences in regard to therapy-determining Lugano Stage.
Details
Originalsprache | Englisch |
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Aufsatznummer | 108775 |
Fachzeitschrift | European journal of radiology |
Jahrgang | 123 |
Publikationsstatus | Veröffentlicht - Feb. 2020 |
Peer-Review-Status | Ja |
Externe IDs
Scopus | 85076631981 |
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Schlagworte
Schlagwörter
- Aged, Diffusion Magnetic Resonance Imaging/methods, Fluorodeoxyglucose F18, Hodgkin Disease/diagnostic imaging, Humans, Magnetic Resonance Imaging, Neoplasm Staging/instrumentation, Positron-Emission Tomography/methods, Retrospective Studies, Sensitivity and Specificity