Differential alterations of amygdala nuclei volumes in acutely ill patients with anorexia nervosa and their associations with leptin levels

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

Abstract

BACKGROUND: The amygdala is a subcortical limbic structure consisting of histologically and functionally distinct subregions. New automated structural magnetic resonance imaging (MRI) segmentation tools facilitate the in vivo study of individual amygdala nuclei in clinical populations such as patients with anorexia nervosa (AN) who show symptoms indicative of limbic dysregulation. This study is the first to investigate amygdala nuclei volumes in AN, their relationships with leptin, a key indicator of AN-related neuroendocrine alterations, and further clinical measures.

METHODS: T1-weighted MRI scans were subsegmented and multi-stage quality controlled using FreeSurfer. Left/right hemispheric amygdala nuclei volumes were cross-sectionally compared between females with AN (n = 168, 12-29 years) and age-matched healthy females (n = 168) applying general linear models. Associations with plasma leptin, body mass index (BMI), illness duration, and psychiatric symptoms were analyzed via robust linear regression.

RESULTS: Globally, most amygdala nuclei volumes in both hemispheres were reduced in AN v. healthy control participants. Importantly, four specific nuclei (accessory basal, cortical, medial nuclei, corticoamygdaloid transition in the rostral-medial amygdala) showed greater volumetric reduction even relative to reductions of whole amygdala and total subcortical gray matter volumes, whereas basal, lateral, and paralaminar nuclei were less reduced. All rostral-medially clustered nuclei were positively associated with leptin in AN independent of BMI. Amygdala nuclei volumes were not associated with illness duration or psychiatric symptom severity in AN.

CONCLUSIONS: In AN, amygdala nuclei are altered to different degrees. Severe volume loss in rostral-medially clustered nuclei, collectively involved in olfactory/food-related reward processing, may represent a structural correlate of AN-related symptoms. Hypoleptinemia might be linked to rostral-medial amygdala alterations.

Details

OriginalspracheEnglisch
Seiten (von - bis)6288-6303
Seitenumfang16
FachzeitschriftPsychological medicine
Jahrgang53
Ausgabenummer13
Frühes Online-Datum5 Dez. 2022
PublikationsstatusVeröffentlicht - 5 Okt. 2023
Peer-Review-StatusJa

Externe IDs

ORCID /0000-0002-2864-5578/work/142233481
ORCID /0000-0003-2132-4445/work/142236356
ORCID /0000-0001-5726-0928/work/142236880
ORCID /0000-0002-5112-405X/work/142242686
ORCID /0000-0002-5413-0359/work/142248935
ORCID /0000-0002-3907-6630/work/142248957
ORCID /0000-0002-5026-1239/work/142250312
Scopus 85172425308
PubMed 36464660

Schlagworte

Ziele für nachhaltige Entwicklung

Schlagwörter

  • Amygdala, FreeSurfer subcortical subsegmentation, amygdala nuclei, anorexia nervosa, brain substructure volumes, structural MRI, Humans, Magnetic Resonance Imaging/methods, Gray Matter/pathology, Amygdala/diagnostic imaging, Leptin, Female, Anorexia Nervosa/diagnostic imaging