Differential Abnormal Pattern of Anterior Cingulate Gyrus Activation in Unipolar and Bipolar Depression: An fMRI and Pattern Classification Approach

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Christian Bürger - , Westfälische Wilhelms-Universität Münster (Autor:in)
  • Ronny Redlich - , Westfälische Wilhelms-Universität Münster (Autor:in)
  • Dominik Grotegerd - , Westfälische Wilhelms-Universität Münster (Autor:in)
  • Susanne Meinert - , Westfälische Wilhelms-Universität Münster (Autor:in)
  • Katharina Dohm - , Westfälische Wilhelms-Universität Münster (Autor:in)
  • Ilona Schneider - , Westfälische Wilhelms-Universität Münster (Autor:in)
  • Dario Zaremba - , Westfälische Wilhelms-Universität Münster (Autor:in)
  • Katharina Förster - , Westfälische Wilhelms-Universität Münster (Autor:in)
  • Judith Alferink - , Westfälische Wilhelms-Universität Münster (Autor:in)
  • Jens Bölte - , Westfälische Wilhelms-Universität Münster (Autor:in)
  • Walter Heindel - , Westfälische Wilhelms-Universität Münster (Autor:in)
  • Harald Kugel - , Westfälische Wilhelms-Universität Münster (Autor:in)
  • Volker Arolt - , Westfälische Wilhelms-Universität Münster (Autor:in)
  • Udo Dannlowski - , Westfälische Wilhelms-Universität Münster, Philipps-Universität Marburg (Autor:in)

Abstract

Distinguishing bipolar disorder from major depressive disorder is a major challenge in psychiatric treatment. Consequently, there has been growing interest in identifying neuronal biomarkers of disorder-specific pathophysiological processes to differentiate affective disorders. Thirty-six depressed bipolar patients, 36 depressed unipolar patients, and 36 matched healthy controls (HCs) participated in an fMRI experiment. Emotional faces served as stimuli in a matching task. We investigated neural activation towards angry, fearful, and happy faces focusing on prototypical regions related to emotion processing, ie, the amygdala and the anterior cingulate gyrus (ACG). Furthermore, we employed a whole-brain and a multivariate pattern classification analysis. Unipolar patients showed abnormally reduced ACG activation toward happy and fearful faces compared with bipolar patients and HCs respectively. Furthermore, the whole-brain analysis revealed significantly increased activation in bipolar patients compared with unipolar patients in the fearful condition in the right frontal and parietal cortex. Moreover, the multivariate pattern classification analysis yielded significant classification rates of up to 72% based on ACG activation elicited by fearful faces. Our results question the rather 'amygdalocentric' neurobiological models of mood disorders. We observed patterns of abnormally reduced ventral and supragenual ACG activation, potentially indicating impaired bottom-up emotion processing and automatic emotion regulation specifically in unipolar but not in bipolar individuals.

Details

OriginalspracheEnglisch
Seiten (von - bis)1399-1408
Seitenumfang10
FachzeitschriftNeuropsychopharmacology
Jahrgang42
Ausgabenummer7
PublikationsstatusVeröffentlicht - Juni 2017
Peer-Review-StatusJa
Extern publiziertJa

Externe IDs

PubMed 28205606

Schlagworte

Ziele für nachhaltige Entwicklung

Bibliotheksschlagworte