Diastereoselective ru-catalyzed cross-metathesis-dihydroxylation sequence. An efficient approach toward enantiomerically enriched syn-diols

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • N. Matthias Neisius - , Universität Stuttgart (Autor:in)
  • Bernd Plietker - , Universität Stuttgart (Autor:in)

Abstract

(Chemical Equation Presented) Sequential catalysis has evolved as a powerful concept within the past years and allows the more efficient use of catalytically active expensive transition metals in organic synthesis. In this paper we present the stereoselective cross-metathesis-dihydroxylation of various olefins with chiral auxiliary substituted acrylamides. The chiral information (i.e., the auxiliary) introduced in the metathesis reactions allows for a stereoselective subsequent RuO4-catalyzed dihydroxylation. The sequence is concluded by an unusual kinetic resolution of the diastereomeric diols obtained in the oxidation reaction. As a consequence a variety of structurally diverse enantiomerically enriched diols are obtained. To the best of our knowledge the results summarized in this paper represent the first highly efficient diastereoselective RuO4-catalyzed oxidation.

Details

OriginalspracheEnglisch
Seiten (von - bis)3218-3227
Seitenumfang10
FachzeitschriftJournal of Organic Chemistry
Jahrgang73
Ausgabenummer8
PublikationsstatusVeröffentlicht - 18 Apr. 2008
Peer-Review-StatusJa
Extern publiziertJa

Externe IDs

ORCID /0000-0001-8423-6173/work/161891585

Schlagworte

ASJC Scopus Sachgebiete