Development and validation of NTCP models for acute side-effects resulting from proton beam therapy of brain tumours

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

Abstract

BACKGROUND: The limited availability of proton beam therapy (PBT) requires individual treatment selection strategies, such as based on normal tissue complication probability (NTCP). We developed and externally validated NTCP models for common acute side-effects following PBT in brain tumour patients in effort to provide guidance on optimising patient quality of life.

METHODS: An exploration cohort including 113 adult brain tumour patients who underwent PBT was investigated for the following endpoints: alopecia, scalp erythema, headache, fatigue and nausea. Dose-volume parameters of associated normal tissues were used for logistic regression modelling. Statistically significant parameters showing high area under the receiver operating characteristic curve (AUC) values in internal cross-validation were externally validated on two cohorts of 71 and 96 patients, respectively.

RESULTS: Statistically significant correlations of dose-volume parameters of the skin for erythema and alopecia were found. In internal cross-validation, the following prognostic parameters were selected: V35Gy (absolute volume receiving 35 Gy) for erythema grade ≥1, D2% (dose to 2% of the volume) for alopecia grade ≥1 and D5% for alopecia grade ≥2. Validation was successful for both cohorts with AUC >0.75. A bivariable model for fatigue grade ≥1 could not be validated externally. No correlations of dose-volume parameters of the brain were seen for headache or nausea.

CONCLUSION: We developed and successfully validated NTCP models for scalp erythema and alopecia in primary brain tumour patients treated with PBT.

Details

OriginalspracheEnglisch
Seiten (von - bis)164-171
Seitenumfang8
FachzeitschriftRadiotherapy and Oncology
Jahrgang130
PublikationsstatusVeröffentlicht - Jan. 2019
Peer-Review-StatusJa

Externe IDs

Scopus 85050119121
ORCID /0000-0002-7017-3738/work/142254001
ORCID /0000-0003-1776-9556/work/171065715

Schlagworte

Schlagwörter

  • Acute Disease, Adolescent, Adult, Aged, Aged, 80 and over, Brain Neoplasms/psychology, Cohort Studies, Female, Humans, Male, Middle Aged, Probability, Proton Therapy/adverse effects, Quality of Life, Radiation Injuries/etiology, Young Adult