BACKGROUND: Ovarian cancer patients face treatment-related challenges such as malnutrition and muscle wasting associated with cancer cachexia. If left untreated, these complications can severely impact quality of life and autonomy. The BENITA study aims to develop and evaluate a tailored exercise and nutrition program during and after first-line chemotherapy. Phase I focused on program development and optimization; Phase II will test its effectiveness in a randomized controlled trial.

METHODS: Semi-structured interviews were conducted with patients, survivors, physicians, nutrition and physiotherapy experts, and a health insurance representative. Thematic analysis following Braun and Clarke was used to identify key insights for program design and implementation.

RESULTS: Patients' motivation to engage in exercise and nutrition was driven by enjoyment and external encouragement. Barriers included chemotherapy-induced fatigue, physical weakness, and psychological strain. Uncertainty about safe training post-surgery was common. Regular support from healthcare professionals was seen as essential for confidence and adherence.

DISCUSSION: Findings highlight the need for a personalized, flexible program tailored to ovarian cancer patients' needs. A blended digital approach combining self-guided elements with professional support could improve implementation, offering customized exercise routines, nutrition plans, and regular check-ins to facilitate patient-centered participation.