Development and Evaluation of a Web-Based Paediatric Drug Information System for Germany

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Julia Zahn - , Universitätsklinikum der Friedrich-Alexander-Universität Erlangen-Nürnberg (Autor:in)
  • Stefan Wimmer - , Universitätsklinikum der Friedrich-Alexander-Universität Erlangen-Nürnberg (Autor:in)
  • Wolfgang Rödle - , Friedrich-Alexander-Universität Erlangen-Nürnberg (Autor:in)
  • Irmgard Toni - , Universitätsklinikum der Friedrich-Alexander-Universität Erlangen-Nürnberg (Autor:in)
  • Brita Sedlmayr - , Institut für Medizinische Informatik und Biometrie, Friedrich-Alexander-Universität Erlangen-Nürnberg (Autor:in)
  • Hans-Ulrich Prokosch - , Friedrich-Alexander-Universität Erlangen-Nürnberg (Autor:in)
  • Wolfgang Rascher - , Universitätsklinikum der Friedrich-Alexander-Universität Erlangen-Nürnberg (Autor:in)
  • Antje Neubert - , Universitätsklinikum der Friedrich-Alexander-Universität Erlangen-Nürnberg (Autor:in)

Abstract

Background: Off-label use is frequent in paediatrics but that does not necessarily mean that the risk-benefit ratio is negative. Nevertheless, evidence-based data is essential for safe drug therapy. In Germany, there is no publicly available compendium providing transparent, evidence-based information for paediatric pharmacotherapy to date. This work describes the development of a web-based paediatric drug information system (PDIS) for Germany and its evaluation by health care professionals (HCP). Methods: Since 2012, a PDIS is being developed by the authors and is supported by the Federal Ministry of Health since 2016. Dosing recommendations were established based on systematic literature reviews and subsequent evaluation by clinical experts. The prototype was evaluated by HCP. Based on the results, the further development was concluded. Results: 92% of HCP believed that the PDIS could improve the quality of prescribing, as currently available information is deficient. Besides the license and formulations, dosing recommendations were the most relevant modules. A dosage calculator was the most wanted improvement. To facilitate sustainability of future development, a collaboration with the Dutch Kinderformularium was established. As of 2021, the database will be available to German HCP. Conclusion: The fundamentals for a German PDIS were established, and vital steps were taken towards successful continuation.

Details

OriginalspracheEnglisch
Aufsatznummer8
Seiten (von - bis)8
Fachzeitschrift Pharmacy : a journal of pharmacy education and practice
Jahrgang9
Ausgabenummer1
PublikationsstatusVeröffentlicht - 5 Jan. 2021
Peer-Review-StatusJa

Externe IDs

PubMedCentral PMC7838899
Mendeley 99d836af-e307-360c-b8c9-092dcc8bc9c3
unpaywall 10.3390/pharmacy9010008