Abstract. Robust and automated point cloud registration methods are required in many geoscience applications using multi-temporal and multi-modal 3D point clouds. Therefore, a 3D keypoint-based coarse registration workflow has been implemented, utilizing the ISS keypoint detector and 3DSmoothNet descriptor. This paper contributes to keypoint-based registration research through variations of the standard workflow proposed in the literature, applying a two-staged strategy of global and local keypoint matching as well as prototypical keypoint projection and fine registration based on ICP. Further, by testing the utilized detector and descriptor on unstructured, multi-temporal and multi-source point clouds with variations in point cloud density, generalization ability is tested outside benchmark data. Therefore, data of the Bøverbreen glacier in Jotunheimen, Norway has been acquired in 2022 and 2023, deploying UAV-based image matching and terrestrial laser scanning. The results show good performance of the implemented robust matching algorithm PROSAC, requiring fewer iterations than the well-known RANSAC approach, but solving the rigid body transformation with TEASER++ is faster and more robust to outliers without demanding pre-knowledge of the data. Further, the results identify the keypoint detection as most limiting factor in speed and accuracy. Summarizing, keypoint-based coarse registration on low density point clouds, applying a global and local matching strategy and transformation estimation using TEASER++ is recommended. Keypoint projection shows potential, increasing number and precision in low density clouds, but has to be more robust. Further research needs to be carried out, focusing on identifying a fast and robust keypoint detector.