Defence against antimicrobial peptides: different strategies in Firmicutes

Publikation: Beitrag in FachzeitschriftÜbersichtsartikel (Review)BeigetragenBegutachtung

Beitragende

  • Ainhoa Revilla-Guarinos - , Departamento de Biotecnología, Instituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC), Consejo Superior de Investigaciones Científicas, Paterna, Universidad Europea de Valencia (Autor:in)
  • Susanne Gebhard - (Autor:in)
  • Thorsten Mascher - , Professur für Allgemeine Mikrobiologie (Autor:in)
  • Manuel Zúñiga - (Autor:in)

Abstract

The Firmicutes constitute a phylum of bacteria that can be found in a wide variety of habitats, from soil to the gastrointestinal tract of animals, where they have to thrive in complex communities. Competition in these communities usually involves the production of compounds such as antimicrobial peptides (AMPs) to eliminate competitor organisms. Animals and plants also produce AMPs to control their associated microbiota. In turn, defence mechanisms have evolved to prevent the action of these compounds. The close association of some Firmicutes with humans as prominent pathogens or commensal organisms has driven a considerable research effort on defence mechanisms used by these bacteria against antimicrobial compounds. This review focuses on the most recent advances on two well-characterized defence mechanisms against AMPs: the modification of the cell wall by D-alanylation and the role of peptide antibiotic-specific adenosine triphosphate-binding cassette transporters.

Details

OriginalspracheEnglisch
Seiten (von - bis)1225-37
Seitenumfang13
FachzeitschriftEnvironmental microbiology
Jahrgang16
Ausgabenummer5
PublikationsstatusVeröffentlicht - Mai 2014
Peer-Review-StatusJa

Externe IDs

Scopus 84898771414

Schlagworte

Schlagwörter

  • ATP-Binding Cassette Transporters/metabolism, Anti-Bacterial Agents/chemistry, Antimicrobial Cationic Peptides/chemistry, Cell Wall/chemistry, Drug Resistance, Bacterial, Gram-Positive Bacteria/drug effects, Membrane Transport Proteins/metabolism, Teichoic Acids/metabolism