Purpose: We evaluated the feasibility of ¹⁸Fluoride Positron Emission Tomography ( ¹⁸F-PET), investigated the characteristic appearance of bony structures, and compared the quality of ¹⁸F-PET images with conventional bone scans (BS). Method: ¹⁸F-PET scans were performed in 59 patients additional to conventional bone scintigraphy. Results: Even very small details in the spine like the spinous and transverse processes were clearly visible with ¹⁸F-PET. Only half of these structures were visualised with BS. When visualising the vertebral bodies of the first rib from the clavicles and the twelfth rib from the kidneys, we arrived at similar results. Hot spots in the skull or at the manubriosternal joint were observed in 29% of the patients without any evidence of trauma, degeneration or metastasis. Conclusion: ¹⁸F-PET shows more details of the skeleton compared to BS. Some hot spots not occurring with BS must be regarded as physiological.