Curcumin and Graphene Oxide Incorporated into Alginate Hydrogels as Versatile Devices for the Local Treatment of Squamous Cell Carcinoma

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Lorenzo Francesco Madeo - , Leibniz-Institut für Festkörper- und Werkstoffforschung Dresden (Autor:in)
  • Patrizia Sarogni - , National Research Council of Italy (CNR) (Autor:in)
  • Giuseppe Cirillo - , University of Calabria (Autor:in)
  • Orazio Vittorio - , University of New South Wales (Autor:in)
  • Valerio Voliani - , National Research Council of Italy (CNR) (Autor:in)
  • Manuela Curcio - , University of Calabria (Autor:in)
  • Tyler Shai-Hee - , University of New South Wales (Autor:in)
  • Bernd Büchner - , Professur für Experimentelle Festkörperphysik (gB/IFW), Leibniz-Institut für Festkörper- und Werkstoffforschung Dresden (Autor:in)
  • Michael Mertig - , Professur für Physikalische Chemie, insbesondere Mess- und Sensortechnik (gB/KSI) (PC6), Kurt-Schwabe-Institut für Mess- und Sensortechnik e.V. Meinsberg (Autor:in)
  • Silke Hampel - , Leibniz-Institut für Festkörper- und Werkstoffforschung Dresden (Autor:in)

Abstract

With the aim of preparing hybrid hydrogels suitable for use as patches for the local treatment of squamous cell carcinoma (SCC)-affected areas, curcumin (CUR) was loaded onto graphene oxide (GO) nanosheets, which were then blended into an alginate hydrogel that was crosslinked by means of calcium ions. The homogeneous incorporation of GO within the polymer network, which was confirmed through morphological investigations, improved the stability of the hybrid system compared to blank hydrogels. The weight loss in the 100–170C temperature range was reduced from 30% to 20%, and the degradation of alginate chains shifted to higher temperatures. Moreover, GO enhanced the stability in water media by counteracting the de-crosslinking process of the polymer network. Cell viability assays showed that the loading of CUR (2.5% and 5% by weight) was able to reduce the intrinsic toxicity of GO towards healthy cells, while higher amounts were ineffective due to the antioxidant/prooxidant paradox. Interestingly, the CUR-loaded systems were found to possess a strong cytotoxic effect in SCC cancer cells, and the sustained CUR release (~50% after 96 h) allowed long-term anticancer efficiency to be hypothesized.

Details

OriginalspracheEnglisch
Aufsatznummer1648
FachzeitschriftMaterials
Jahrgang15
Ausgabenummer5
PublikationsstatusVeröffentlicht - 22 Feb. 2022
Peer-Review-StatusJa

Externe IDs

PubMed 35268879

Schlagworte

Ziele für nachhaltige Entwicklung

Schlagwörter

  • Alginate hydrogels, Curcumin, Graphene oxide, Hybrid hydrogels, Ionic crosslinking, Squamous cell carcinoma

Bibliotheksschlagworte