Cross-coupling reactions as valuable tool for the preparation of PET radiotracers
Publikation: Beitrag in Fachzeitschrift › Übersichtsartikel (Review) › Beigetragen › Begutachtung
Beitragende
Abstract
The increasing application of positron emission tomography (PET) in nuclear medicine has stimulated the extensive development of a multitude of new radiotracers and novel radiolabeling procedures with the most prominent short-lived positron emitters carbon-11 and fluorine-18. Radiolabeling with these radionuclides represents a remarkable challenge. Special attention has to be paid to synthesis time and specific labeling techniques due to the short physical half life of the respective radionuclides ¹¹C (t(½) = 20.4 min) and ¹⁸F (t½) = 109.8 min). In the past, numerous transition metal-catalyzed reactions were employed in organic chemistry, even though only a handful of these coupling reactions were adopted in radiochemical practice. Thus, the implementation of modern synthesis methods like cross-coupling reactions offers the possibility to develop a wide variety of novel radiotracers. The introduction of catalysts based on transition metal complexes bears a high potential for rapid, efficient, highly selective and functional group-tolerating incorporation of carbon-11 and fluorine-18 into target molecules. This review deals with design, application and improvement of transition metal-mediated carbon-carbon as well as carbon-heteroatom cross-coupling reactions as a labeling feature with the focus on the preparation of radiolabeled compounds for molecular imaging.
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 1129-65 |
Seitenumfang | 37 |
Fachzeitschrift | Molecules |
Jahrgang | 16 |
Ausgabenummer | 2 |
Publikationsstatus | Veröffentlicht - 26 Jan. 2011 |
Peer-Review-Status | Ja |
Extern publiziert | Ja |
Externe IDs
PubMedCentral | PMC6259626 |
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Scopus | 79952178716 |
ORCID | /0000-0002-6432-5694/work/146644248 |
Schlagworte
Schlagwörter
- Carbon Radioisotopes/chemistry, Fluorine Radioisotopes/chemistry, Isotope Labeling/methods, Molecular Structure, Positron-Emission Tomography/methods, Radiopharmaceuticals/chemistry