Covid-19 affects taste independently of smell: results from a combined chemosensory home test and online survey from a global cohort (N=10,953)

Publikation: Vorabdruck/Dokumentation/BerichtVorabdruck (Preprint)

Beitragende

  • Ha Nguyen - (Autor:in)
  • Javier Albayay - (Autor:in)
  • Richard Höchenberger - (Autor:in)
  • Surabhi Bhutani - (Autor:in)
  • Sanne Boesveldt - (Autor:in)
  • Niko A Busch - (Autor:in)
  • Ilja Croijmans - (Autor:in)
  • Keiland W Cooper - (Autor:in)
  • Jasper H B de Groot - (Autor:in)
  • Michael C Farruggia - (Autor:in)
  • Alexander W Fjaeldstad - (Autor:in)
  • John E Hayes - (Autor:in)
  • Thomas Hummel - , Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde (Autor:in)
  • Paule V Joseph - (Autor:in)
  • Tatiana K Laktionova - (Autor:in)
  • Thierry Thomas-Danguin - (Autor:in)
  • Maria G Veldhuizen - (Autor:in)
  • Vera V Voznessenskaya - (Autor:in)
  • Valentina Parma - (Autor:in)
  • M Yanina Pepino - (Autor:in)
  • Kathrin Ohla - (Autor:in)

Abstract

People often confuse smell loss with taste loss, so it is unclear how much gustatory function is reduced in patients self-reporting taste loss. Our pre-registered cross-sectional study design included an online survey in 12 languages with instructions for self-administering chemosensory tests with ten household items. Between June 2020 and March 2021, 10,953 individuals participated. Of these, 3,356 self-reported a positive and 602 a negative COVID-19 diagnosis (COVID+ and COVID-, respectively); 1,267 were awaiting test results (COVID?). The rest reported no respiratory illness and were grouped by symptoms: sudden smell/taste changes (STC, N=4,445), other symptoms excluding smell or taste loss (OthS, N=832), and no symptoms (NoS, N=416). Taste, smell, and oral irritation intensities and self-assessed abilities were rated on visual analog scales. Compared to the NoS group, COVID+ was associated with a 21% reduction in taste (95% Confidence Interval (CI): 15-28%), 47% in smell (95%-CI: 37-56%), and 17% in oral irritation (95%-CI: 10-25%) intensity. In all groups, perceived intensity of smell (r=0.84), taste (r=0.68), and oral irritation (r=0.37) was correlated. Our findings suggest most reports of taste dysfunction with COVID-19 were genuine and not due to misinterpreting smell loss as taste loss (i.e., a classical taste-flavor confusion). Assessing smell and taste intensity of household items is a promising, cost-effective screening tool that complements self-reports and helps to disentangle taste loss from smell loss. However, it does not replace standardized validated psychophysical tests.

Details

OriginalspracheEnglisch
PublikationsstatusVeröffentlicht - 18 Jan. 2023
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Externe IDs

PubMedCentral PMC9882440
medrxiv 10.1101/2023.01.16.23284630_v1
unpaywall 10.1101/2023.01.16.23284630
ORCID /0000-0001-9713-0183/work/146645499

Schlagworte

Ziele für nachhaltige Entwicklung

Schlagwörter

  • infectious diseases