Covid-19 affects taste independent of taste-smell confusions: results from a combined chemosensory home test and online survey from a large global cohort

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Ha Nguyen - , Monell Chemical Senses Center (Autor:in)
  • Javier Albayay - , Università degli Studi di Trento (Autor:in)
  • Richard Höchenberger - , Commissariat à l’énergie atomique et aux énergies alternatives (CEA) (Autor:in)
  • Surabhi Bhutani - , San Diego State University (Autor:in)
  • Sanne Boesveldt - , Wageningen University & Research (WUR) (Autor:in)
  • Niko A. Busch - , Westfälische Wilhelms-Universität Münster (Autor:in)
  • Ilja Croijmans - , Radboud University Nijmegen (Autor:in)
  • Keiland W. Cooper - , University of California at Irvine (Autor:in)
  • Jasper H.B. De Groot - , Radboud University Nijmegen (Autor:in)
  • Michael C. Farruggia - , Yale University (Autor:in)
  • Alexander W. Fjaeldstad - , University Clinic for Flavour (Autor:in)
  • John E. Hayes - , Pennsylvania State University (Autor:in)
  • Thomas Hummel - , Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde (Autor:in)
  • Paule V. Joseph - , National Institutes of Health (NIH) (Autor:in)
  • Tatiana K. Laktionova - , Russian Academy of Sciences (Autor:in)
  • Thierry Thomas-Danguin - , INRAE CSGA (Autor:in)
  • Maria G. Veldhuizen - , Mersin University (Autor:in)
  • Vera V. Voznessenskaya - , Russian Academy of Sciences (Autor:in)
  • Valentina Parma - , Monell Chemical Senses Center (Autor:in)
  • M. Yanina Pepino - , University of Illinois at Urbana-Champaign (Autor:in)
  • Kathrin Ohla - , Pennsylvania State University, Universität der Bundeswehr Hamburg (Helmut-Schmidt Universität Hamburg), Dsm-firmenich (Autor:in)

Abstract

People often confuse smell loss with taste loss, so it is unclear how much gustatory function is reduced in patients self-reporting taste loss. Our pre-registered cross-sectional study design included an online survey in 12 languages with instructions for self-Administering chemosensory tests with 10 household items. Between June 2020 and March 2021, 10,953 individuals participated. Of these, 5,225 self-reported a respiratory illness and were grouped based on their reported COVID test results: COVID-positive (COVID+, N = 3,356), COVID-negative (COVID-, N = 602), and COVID unknown for those waiting for a test result (COVID?, N = 1,267). The participants who reported no respiratory illness were grouped by symptoms: sudden smell/taste changes (STC, N = 4,445), other symptoms excluding smell or taste changes (OthS, N = 832), and no symptoms (NoS, N = 416). Taste, smell, and oral irritation intensities and self-Assessed abilities were rated on visual analog scales. Compared to the NoS group, COVID+ was associated with a 21% reduction in taste (95% confidence interval (CI): 15-28%), 47% in smell (95% CI: 37-56%), and 17% in oral irritation (95% CI: 10-25%) intensity. There were medium to strong correlations between perceived intensities and self-reported abilities (r = 0.84 for smell, r = 0.68 for taste, and r = 0.37 for oral irritation). Our study demonstrates that COVID-19-positive individuals report taste dysfunction when self-Tested with stimuli that have little to none olfactory components. Assessing the smell and taste intensity of household items is a promising, cost-effective screening tool that complements self-reports and may help to disentangle taste loss from smell loss. However, it does not replace standardized validated psychophysical tests.

Details

OriginalspracheEnglisch
Aufsatznummerbjad020
Seitenumfang11
FachzeitschriftChemical senses
Jahrgang48 (2023)
PublikationsstatusVeröffentlicht - 23 Juni 2023
Peer-Review-StatusJa

Externe IDs

PubMed 37350646
ORCID /0000-0001-9713-0183/work/146645756
WOS 001068879500003
WOS 001039907700001

Schlagworte

Schlagwörter

  • Ageusia, Anosmia, Chemesthesis, Gustation, Olfaction, Taste-smell confusion, Humans, COVID-19/diagnosis, Smell, Taste, Ageusia, Anosmia, SARS-CoV-2, Cross-Sectional Studies, Olfaction Disorders/diagnosis, Taste Disorders/diagnosis