Conduct problems are associated with accelerated thinning of emotion-related cortical regions in a community-based sample of adolescents

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung


  • Matthew D Albaugh - , University of Vermont (Autor:in)
  • James J Hudziak - , University of Vermont (Autor:in)
  • Philip A Spechler - , University of Vermont (Autor:in)
  • Bader Chaarani - , University of Vermont (Autor:in)
  • Claude Lepage - , McGill University (Autor:in)
  • Seun Jeon - , McGill University (Autor:in)
  • Pierre Rioux - , McGill University (Autor:in)
  • Alan C Evans - , McGill University (Autor:in)
  • Tobias Banaschewski - , Nationales Zentrum für Tumorerkrankungen (NCT) Heidelberg (Autor:in)
  • Arun L W Bokde - , Trinity College Dublin (Autor:in)
  • Sylvane Desrivières - , King's College Hospital NHS Foundation Trust (Autor:in)
  • Herta Flor - , Nationales Zentrum für Tumorerkrankungen (NCT) Heidelberg (Autor:in)
  • Penny Gowland - , Park University, Missouri (Autor:in)
  • Andreas Heinz - , Charité – Universitätsmedizin Berlin (Autor:in)
  • Bernd Ittermann - , Physikalisch-Technische Bundesanstalt (Autor:in)
  • Jean-Luc Martinot - , Université Paris-Saclay (Autor:in)
  • Marie-Laure Paillère Martinot - , Université Paris-Saclay (Autor:in)
  • Frauke Nees - , Nationales Zentrum für Tumorerkrankungen (NCT) Heidelberg (Autor:in)
  • Dimitri Papadopoulos Orfanos - , Commissariat à l’énergie atomique et aux énergies alternatives (CEA) (Autor:in)
  • Luise Poustka - , Universitätsmedizin Göttingen (Autor:in)
  • Sabina Millenet - , Nationales Zentrum für Tumorerkrankungen (NCT) Heidelberg (Autor:in)
  • Juliane H Fröhner - , Klinik und Poliklinik für Psychiatrie und Psychotherapie (Autor:in)
  • Michael N Smolka - , Klinik und Poliklinik für Psychiatrie und Psychotherapie (Autor:in)
  • Henrik Walter - , Mental Health Institute Berlin GmbH (Autor:in)
  • Robert Whelan - , Trinity College Dublin (Autor:in)
  • Gunter Schumann - , Zhongshan Hospital at Fudan University (Autor:in)
  • Alexandra S Potter - , University of Vermont (Autor:in)
  • Hugh Garavan - , University of Vermont (Autor:in)


Few studies have examined the association between conduct problems and cerebral cortical development. Herein, we characterize the association between age-related brain change and conduct problems in a large longitudinal, community-based sample of adolescents. 1,039 participants from the IMAGEN study possessed psychopathology and surface-based morphometric data at study baseline (M = 14.42 years, SD = 0.40; 559 females) and 5-year follow-up. Self-reports of conduct problems were obtained using the Strengths and Difficulties Questionnaire (SDQ). Vertex-level linear mixed effects models were implemented using the Matlab toolbox, SurfStat. To investigate the extent to which cortical thickness maturation was qualified by dimensional measures of conduct problems, we tested for an interaction between age and SDQ Conduct Problems (CP) score. There was no main effect of CP score on cortical thickness; however, a significant "Age by CP" interaction was revealed in bilateral insulae, left inferior frontal gyrus, left rostral anterior cingulate, left posterior cingulate, and bilateral inferior parietal cortices. Across regions, follow-up analysis revealed higher levels of CP were associated with accelerated age-related thinning. Findings were not meaningfully altered when controlling for alcohol use, co-occurring psychopathology, and socioeconomic status. Results may help to further elucidate neurodevelopmental patterns linking adolescent conduct problems with adverse adult outcomes.


Seiten (von - bis)111614
FachzeitschriftPsychiatry research. Neuroimaging
PublikationsstatusVeröffentlicht - Apr. 2023

Externe IDs

Scopus 85148338220
ORCID /0000-0001-5398-5569/work/150329574
ORCID /0000-0002-8493-6396/work/150330272



  • Adult, Female, Adolescent, Humans, Magnetic Resonance Imaging/methods, Cerebral Cortex/pathology, Prefrontal Cortex/pathology, Emotions, Parietal Lobe