Spacer fabrics are 3D technical textiles. Their compressibility can be adjusted during production, e.g. by changing the machine parameters or using different yarn materials. These steps require extensive knowledge of the production process and are difficult to change. This research takes an innovative approach to influence the compression behavior individually. It introduces the concept of creating locally sectioned spacer fabrics through sewing. The compression behavior of these fabrics, with seam distances of 43 mm, 24 mm, and 18 mm, was thoroughly tested and evaluated. A two-step numerical model was developed to accurately predict the compression behavior of these spacer fabrics with seams. The model’s validity was confirmed through experimental compression tests. The results show that spacer fabrics with a larger number of seams absorb compressive forces less. The numerical model agrees well with the experimental results and proves its applicability. Using the numerical model seam patterns for larger spacer fabrics can be tested and individual modified spacer fabrics can be produced.