Comparison of chocolate to cacao-free white chocolate in Parkinson's disease: A single-dose, investigator-blinded, placebo-controlled, crossover trial

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Martin Wolz - , Technische Universität Dresden (Autor:in)
  • Christine Schleiffer - , Technische Universität Dresden (Autor:in)
  • Lisa Klingelhöfer - , Klinik und Poliklinik für Neurologie (Autor:in)
  • Christine Schneider - , Technische Universität Dresden (Autor:in)
  • Florian Proft - , Julius-Maximilians-Universität Würzburg (Autor:in)
  • Uta Schwanebeck - , Technische Universität Dresden (Autor:in)
  • Heinz Reichmann - , Klinik und Poliklinik für Neurologie (Autor:in)
  • Peter Riederer - , Julius-Maximilians-Universität Würzburg (Autor:in)
  • Alexander Storch - , Technische Universität Dresden, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) - Standort Dresden (Autor:in)

Abstract

A previous questionnaire study suggests an increased chocolate consumption in Parkinson's disease (PD). The cacao ingredient contains caffeine analogues and biogenic amines, such as β-phenylethylamine, with assumed antiparkinsonian effects. We thus tested the effects of 200 g of chocolate containing 80 % of cacao on UPDRS motor score after 1 and 3 h in 26 subjects with moderate non-fluctuating PD in a mono-center, single-dose, investigator-blinded crossover study using cacao-free white chocolate as placebo comparator. At 1 h after chocolate intake, mean UPDRS motor scores were mildly decreased compared to baseline in both treatments with significant results only for dark chocolate [- 1.3 (95 % CI 0.18-2.52, RMANOVAF = 4.783, p = 0.013, Bonferroni p = 0.021 for 1 h values)]. A 2 × 2-cross-over analysis revealed no significant differences between both treatments [-0.54 ± 0.47 (95 % CI-1.50 to 0.42), p = 0.258]. Similar results were obtained at 3 h after intake. β-phen-ylethylamine blood levels were unaltered. Together, chocolate did not show significant improvement over white cacao-free chocolate in PD motor function.

Details

OriginalspracheEnglisch
Seiten (von - bis)2447-2451
Seitenumfang5
FachzeitschriftJournal of Neurology
Jahrgang259
Ausgabenummer11
PublikationsstatusVeröffentlicht - Nov. 2012
Peer-Review-StatusJa

Externe IDs

Scopus 84868194050
PubMed 22584952

Schlagworte

ASJC Scopus Sachgebiete

Schlagwörter

  • Biogenic amines, Chocolate, Investigator-blind randomized clinical trial, Parkinson's disease, Pharmacological effects