Colocalization of Tau but Not β-Amyloid with Cortical Superficial Siderosis in a Case with Probable CAA

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Matthias Brendel - , Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Cihan Catak - , Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Leonie Beyer - , Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Jennifer Linn - , Institut und Poliklinik für Diagnostische und Interventionelle Neuroradiologie, Technische Universität Dresden (Autor:in)
  • Hannes Wahl - , Institut und Poliklinik für Diagnostische und Interventionelle Neuroradiologie, Technische Universität Dresden (Autor:in)
  • Daniel Janowitz - , Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Axel Rominger - , Ludwig-Maximilians-Universität München (LMU), Universität Bern (Autor:in)
  • Marianne Patt - , Universität Leipzig (Autor:in)
  • Henryk Barthel - , Universität Leipzig (Autor:in)
  • Osama Sabri - , Universität Leipzig (Autor:in)
  • Peter Bartenstein - , Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Frank Arne Wollenweber - , Ludwig-Maximilians-Universität München (LMU), Dr. Horst Schmidt Klinik GmbH (Autor:in)

Abstract

Cortical superficial siderosis (cSS) is a common feature in patients with cerebral amyloid angiopathy (CAA). The correlation between β-amyloid and/or tau pathology and the occurrence of cSS is unclear. We report on an 80-year-old male patient who was diagnosed with probable CAA according to modified Boston criteria and underwent longitudinal magnetic resonance imaging, amyloid positron emission tomography (PET), and additional tau PET imaging. Amyloid deposition presented predominantly in the contralateral hemisphere not affected by cSS. In contrast, tau deposition was predominantly overlapping with brain regions affected by cSS. Amyloid deposition was not different in the vicinity of cSS whereas tau depositions were elevated in the vicinity of CSS-affected regions compared to non-cSS-affected brain regions. This case of probable CAA suggests that cSS may be associated with a locally elevated tau pathology but not with increased fibrillary amyloid deposition.

Details

OriginalspracheEnglisch
Seiten (von - bis)232-237
Seitenumfang6
FachzeitschriftCase Reports in Neurology
Jahrgang12
Ausgabenummer2
PublikationsstatusVeröffentlicht - 2020
Peer-Review-StatusJa

Externe IDs

ORCID /0000-0002-4897-1119/work/146166931

Schlagworte

ASJC Scopus Sachgebiete