Collective oscillations of processive molecular motors

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • O. Campàs - , Harvard University, Institut Curie (Autor:in)
  • C. Leduc - , Max Planck Institute of Molecular Cell Biology and Genetics, Institut Curie (Autor:in)
  • P. Bassereau - , Institut Curie (Autor:in)
  • J. F. Joanny - , Institut Curie (Autor:in)
  • J. Prost - , ESPCI, Institut Curie (Autor:in)

Abstract

We present both a theoretical and an experimental study of the long time behavior of membrane nanotubes pulled from giant unilamellar vesicles by molecular motors. Experimentally, two types of behaviors are observed, either tubes stall at a finite length or they undergo periodic oscillations. Theoretically we write the equations for the tube dynamics as a two-dimensional dynamical system where the variables are the tube length (or the force required to pull the tube at a given length) and the number of motors at the tip pulling the tube. We construct stability diagrams showing the stalling and oscillating states and present an example of oscillations in a non-linear regime. These results can explain the membrane tube retractions and oscillations observed in living cells.

Details

OriginalspracheEnglisch
Seiten (von - bis)163-178
Seitenumfang16
FachzeitschriftBiophysical Reviews and Letters
Jahrgang4
Ausgabenummer1-2
PublikationsstatusVeröffentlicht - 2009
Peer-Review-StatusJa
Extern publiziertJa

Schlagworte