Clinical relevance of circulating MACC1 and S100A4 transcripts for ovarian cancer

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

Abstract

Metastasis-associated in colon cancer 1 (MACC1) and S100 calcium-binding protein A4 (S100A4) are prominent inducers of tumor progression and metastasis. For the first time, we systematically tracked circulating serum levels of MACC1 and S100A4 transcripts in the course of surgery and chemotherapy and analyzed their clinical relevance for ovarian cancer. MACC1 and S100A4 transcripts were quantified in a total of 318 serum samples from 79 ovarian cancer patients by RT-qPCR and digital droplet PCR, respectively. MACC1 and S100A4 transcripts were significantly elevated in serum of ovarian cancer patients, compared to healthy controls (P = 0.024; P < 0.001). At primary diagnosis, high levels of MACC1 or S100A4 correlated with advanced FIGO stage (P = 0.042; P = 0.008), predicted suboptimal debulking surgery and indicated shorter progression-free survival (PFS; P = 0.003; P = 0.001) and overall survival (OS; P = 0.001; P = 0.002). This is the first study in ovarian cancer to propose circulating MACC1 and S100A4 transcripts as potential liquid biopsy markers.

Details

OriginalspracheEnglisch
Seiten (von - bis)1268-1279
Seitenumfang12
FachzeitschriftMolecular oncology
Jahrgang13
Ausgabenummer5
PublikationsstatusVeröffentlicht - Mai 2019
Peer-Review-StatusJa

Externe IDs

PubMed 30927479

Schlagworte

Ziele für nachhaltige Entwicklung

Schlagwörter

  • blood-based biomarker, MACC1, ovarian cancer, prognosis, S100A4, survival