Clinical Progression and Outcome of Hospitalized Patients Infected with SARS-CoV-2 Omicron Variant in Shanghai, China

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Jiasheng Shao - , Shanghai University of Medicine and Health Sciences (Autor:in)
  • Rong Fan - , Professur für Biotechnologische Genomik (Autor:in)
  • Jianrong Hu - , Shanghai University of Medicine and Health Sciences (Autor:in)
  • Tiejun Zhang - , Fudan University (Autor:in)
  • Catherine Lee - , University of Georgia (Autor:in)
  • Xuyuan Huang - , Shanghai Jiao Tong University (Autor:in)
  • Fei Wang - , Jiading District Central Hospital (Autor:in)
  • Haiying Liang - , Shanghai University of Medicine and Health Sciences (Autor:in)
  • Ye Jin - , Shanghai University of Medicine and Health Sciences (Autor:in)
  • Ying Jiang - , Shanghai University of Medicine and Health Sciences (Autor:in)
  • Yanhua Gu - , Jiading District Central Hospital (Autor:in)
  • Gang Huang - , Shanghai University of Medicine and Health Sciences (Autor:in)

Abstract

Background: Studies on the Omicron variant infection have generally been restricted to descriptions of its initial clinical and epidemiological characteristics. We investigated the timeline-related progression and clinical outcome in hospitalized individuals with the Omicron variant. Methods: We conducted a retrospective, single-centered study including 226 laboratory-confirmed cases with the Omicron variant between 6 April and 11 May 2022 in Shanghai, China. The final date of follow-up was 30 May 2022. Results: Among 226 enrolled patients, the median age was 52 years, and 118 (52.2%) were female. The duration from onset of symptoms to hospitalization was 3 days (interquartile range (IQR): 2–4 days) for symptomatic patients. Cough occurred in 168 patients (74.3%). The median interval to negative reverse-transcriptase PCR tests of nasopharynx swab was 10 days ((IQR): 8–13 days). No radiographic progressions were found in 196 patients on the 7th day after onset of symptoms. The median duration of fever in all participants was 5 days (IQR: 4–6 days). The median PCR conversion time of Paxlovid-treated patients was 8 days (IQR: 7–10 days) compared with that of a traditional Chinese herb medicine lianhuaqingwen (10 days, IQR: 8–13 days) (p = 0.00056). Booster vaccination can significantly decrease the severity of Omicron infection when compared with unvaccinated patients (p = 0.009). In multivariate logistic analysis, erythrocyte sedimentation rate (ESR) (OR = 1.05) was independently related to the severity of the infection. Conclusions: The majority of clinical symptoms of Omicron infection were not severe. Early and aggressive administration of Paxlovid can significantly reduce the PCR conversion time. Booster vaccination should also be highly recommended in the population over 14 years old.

Details

OriginalspracheEnglisch
Aufsatznummer1409
FachzeitschriftVaccines : open access journal
Jahrgang10
Ausgabenummer9
PublikationsstatusVeröffentlicht - 28 Aug. 2022
Peer-Review-StatusJa

Externe IDs

Scopus 85138748804

Schlagworte

Ziele für nachhaltige Entwicklung