Clinical Outcomes after Multivalve Surgery in Octogenarians: Evaluating the Need for a Paradigm Shift

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung


  • Ali Taghizadeh-Waghefi - , Herzzentrum Dresden GmbH – Universitätsklinik (Autor:in)
  • Asen Petrov - , Klinik für Kardiochirurgie (am Herzzentrum), Universitätsklinikum Carl Gustav Carus Dresden, Herzzentrum Dresden GmbH – Universitätsklinik (Autor:in)
  • Sebastian Arzt - , Herzzentrum Dresden GmbH – Universitätsklinik (Autor:in)
  • Konstantin Alexiou - , Herzzentrum Dresden GmbH – Universitätsklinik (Autor:in)
  • Sems-Malte Tugtekin - , Herzzentrum Dresden GmbH – Universitätsklinik (Autor:in)
  • Klaus Matschke - , Medizinische Klinik mit Schwerpunkt Kardiologie (am Herzzentrum), Universitätsklinikum Carl Gustav Carus Dresden, Herzzentrum Dresden GmbH – Universitätsklinik (Autor:in)
  • Utz Kappert - , Herzzentrum Dresden GmbH – Universitätsklinik (Autor:in)
  • Manuel Wilbring - , Herzzentrum Dresden GmbH – Universitätsklinik (Autor:in)


(1) Background: this study addresses the lack of comprehensive research on outcomes in octogenarians undergoing cardiac surgery for multivalvular disease, emphasizing the need for a critical examination of the intervention's overall worth in this aging population. (2) Methods: By analyzing short-term and mid-term data from 101 consecutive octogenarian patients undergoing multivalve surgery, the study identifies predictors for in-hospital and one-year mortality. (3) Results: In-hospital mortality increased fourfold with the occurrence of at least one postoperative complication. Octogenarians undergoing multivalve surgery experienced an in-hospital mortality rate of 13.9% and an overall one-year mortality rate of 43.8%. Postoperative delirium was identified as an independent risk factor, contributing to elevated risks of both in-hospital and one-year mortality. Prolonged surgical procedure time emerged as an independent risk factor associated with increased in-hospital mortality. Continuous veno-venous hemodialysis showed an independent impact on in-hospital mortality. Both re-intubation and the transfusion of packed red blood cells were identified as independent risk factors for one-year mortality. (4) Conclusions: This study urges a critical examination of the justification for multivalve surgeries in high-risk elderly patients, emphasizing a paradigm shift. It advocates for interdisciplinary collaboration and innovative strategies, such as staged hybrid procedures, to improve therapeutic approaches for this challenging patient group to achieve a better therapeutic outcome for these patients.


FachzeitschriftJournal of clinical medicine
PublikationsstatusVeröffentlicht - 27 Jan. 2024

Externe IDs

PubMedCentral PMC10856504
Scopus 85184710788