Patients with pancreatic cancer usually have a poor prognosis. Therefore, it remains questionable whether quality control of the oncological treatment of pancreatic cancer patients is of any importance compared to the aggressive tumor biology. Interestingly, numerous studies and data revealed a clear relationship between hospital volume and outcome for patients with pancreatic cancer. Beside surgeon's experience, the experience and quality of the treating pathologist, oncologist, radiologist and the whole multidisciplinary team also seems to play an important role. Pancreatic cancer should only be treated in experienced and specialised centers in order to provide adequate oncological therapy and to improve long term prognosis of the patients.