Chemical Modification of Hyaluronan and Their Biomedical Applications

Publikation: Beitrag in FachzeitschriftÜbersichtsartikel (Review)BeigetragenBegutachtung

Beitragende

Abstract

Hyaluronan, the extracellular matrix glycosaminoglycan, is an important structural component of many tissues playing a critical role in a variety of biological contexts. This makes hyaluronan, which can be biotechnologically produced in large scale, an attractive starting polymer for chemical modifications. This review provides a broad overview of different synthesis strategies used for modulating the biological as well as material properties of this polysaccharide. We discuss current advances and challenges of derivatization reactions targeting the primary and secondary hydroxyl groups or carboxylic acid groups and the N-acetyl groups after deamidation. In addition, we give examples for approaches using hyaluronan as biomedical polymer matrix and consequences of chemical modifications on the interaction of hyaluronan with cells via receptor-mediated signaling. Collectively, hyaluronan derivatives play a significant role in biomedical research and applications indicating the great promise for future innovative therapies.

Details

OriginalspracheEnglisch
Aufsatznummer830671
Seitenumfang20
FachzeitschriftFrontiers in chemistry
Jahrgang10
Ausgabenummer10
PublikationsstatusVeröffentlicht - Nov. 2022
Peer-Review-StatusJa

Externe IDs

PubMedCentral PMC8873528
Scopus 85125230466
ORCID /0000-0002-5611-9903/work/142244055
Mendeley 156647c8-4340-3552-bb9e-36dbdff17096