Characterization of the LPS-induced inflammation of the adrenal gland in mice

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

Abstract

Systemic administration of endotoxin, which closely mimics the bacteria-induced systemic inflammatory response syndrome (SIRS) can ultimately lead to organ failure. Adrenal gland insufficiency is frequently diagnosed in critically ill patients; however, the underlying mechanisms are still unclear. In the present study, we studied comprehensively the characteristics of adrenal gland dysregulation, including inflammation, leukocyte infiltration and cell death in the adrenal glands in the course of LPS-induced systemic inflammation in mice. LPS enhanced expression of many proinflammatory cytokines, chemokines and adhesion molecules, which resulted in rapid recruitment of leukocytes into the adrenal gland. Furthermore, LPS-mediated inflammation was associated with increased apoptosis of adrenocortical and chromaffin cells. Our results performed in mice, suggest that LPS-induced adrenal gland inflammation and cell death might be mechanisms potentially involved in the adrenal gland dysfunction in patients with sepsis.

Details

OriginalspracheEnglisch
Seiten (von - bis)228-235
Seitenumfang8
FachzeitschriftMolecular and Cellular Endocrinology
Jahrgang371
Ausgabenummer1-2
PublikationsstatusVeröffentlicht - 22 Mai 2013
Peer-Review-StatusJa

Externe IDs

researchoutputwizard legacy.publication#54903
Scopus 84876084376
PubMed 23295830

Schlagworte

Schlagwörter

  • Adrenal gland insufficiency, Chemokines, Endotoxemia, Leukocyte recruitment, The immune-adrenal crosstalk, Vasculature