Weight reduction by employing lighter alloys, composites, or stronger materials of a smaller cross in novel, multi-material design sections is increasingly becoming the key to success in nowadays material engineering. This is particularly representative for aircraft, automotive and train structures where energy efficiency is essential in order to minimize operating costs. In recent years, tremendous progress has been made in the technology of lightweight materials, in the case of both metals and composites. However, some products require the combination of both groups of these materials, while at the same time achieving a negligible decrease of achieved synergic properties. Therefore, the development of a suitable joining method using different composites is indispensable. For the manufacturing of the metal matrix composites and lightweight alloys specimens, the advanced Gas Pressure Infiltration method has been used. The metal/CFRP multi structural composite has been prototyped by the adapted Resin Transfer Moulding (RTM) method. This paper presents an experimental study of the novel joints of dissimilar materials, such as Carbon Fibre Reinforced Polymers (CFRP), lightweight metal alloys, and Metal Matrix Composites (MMC), manufactured by the help of adequate methods. This research focuses on the advantages and development of the joining of dissimilar advanced lightweight materials. The specific objective of this paper is to evaluate the quality and durability of joints between CFRP and metal alloy/MMC. There are reasonable evidences to conclude that the durability of the joints being investigated strongly depends on the arrangement of used materials, and type of components used.