Cetuximab Plus Irinotecan, Fluorouracil, and Leucovorin As First-Line Treatment for Metastatic Colorectal Cancer: Updated Analysis of Overall Survival According to Tumor KRAS and BRAF Mutation Status

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Eric Van Cutsem - , Universitair Ziekenhuis (UZ) Leuven (Autor:in)
  • Claus-Henning Köhne - (Autor:in)
  • István Láng - (Autor:in)
  • Gunnar Folprecht - , Medizinische Klinik und Poliklinik I (Autor:in)
  • Marek P Nowacki - (Autor:in)
  • Stefano Cascinu - (Autor:in)
  • Igor Shchepotin - (Autor:in)
  • Joan Maurel - (Autor:in)
  • David Cunningham - (Autor:in)
  • Sabine Tejpar - (Autor:in)
  • Michael Schlichting - (Autor:in)
  • Angela Zubel - (Autor:in)
  • Ilhan Celik - (Autor:in)
  • Philippe Rougier - (Autor:in)
  • Fortunato Ciardiello - (Autor:in)

Abstract

PURPOSE: The addition of cetuximab to irinotecan, fluorouracil, and leucovorin (FOLFIRI) as first-line treatment for metastatic colorectal cancer (mCRC) was shown to reduce the risk of disease progression and increase the chance of response in patients with KRAS wild-type disease. An updated survival analysis, including additional patients analyzed for tumor mutation status, was undertaken.

PATIENTS AND METHODS: Patients were randomly assigned to receive FOLFIRI with or without cetuximab. DNA was extracted from additional slide-mounted tumor samples previously used to assess epidermal growth factor receptor expression. Clinical outcome according to the tumor mutation status of KRAS and BRAF was assessed in the expanded patient series.

RESULTS: The ascertainment rate of patients analyzed for tumor KRAS status was increased from 45% to 89%, with mutations detected in 37% of tumors. The addition of cetuximab to FOLFIRI in patients with KRAS wild-type disease resulted in significant improvements in overall survival (median, 23.5 v 20.0 months; hazard ratio [HR], 0.796; P = .0093), progression-free survival (median, 9.9 v 8.4 months; HR, 0.696; P = .0012), and response (rate 57.3% v 39.7%; odds ratio, 2.069; P < .001) compared with FOLFIRI alone. Significant interactions between KRAS status and treatment effect were noted for all key efficacy end points. KRAS mutation status was confirmed as a powerful predictive biomarker for the efficacy of cetuximab plus FOLFIRI. BRAF tumor mutation was a strong indicator of poor prognosis.

CONCLUSION: The addition of cetuximab to FOLFIRI as first-line therapy improves survival in patients with KRAS wild-type mCRC. BRAF tumor mutation is an indicator of poor prognosis.

Details

OriginalspracheEnglisch
Seiten (von - bis)2011-2019
Seitenumfang9
FachzeitschriftJournal of Clinical Oncology
Jahrgang29
Ausgabenummer15
PublikationsstatusVeröffentlicht - 20 Mai 2011
Peer-Review-StatusJa

Externe IDs

Scopus 79956298812
PubMed 21502544
WOS 000290716900029
ORCID /0000-0002-9321-9911/work/142251938

Schlagworte

Ziele für nachhaltige Entwicklung

Schlagwörter

  • Chemotherapy, Panitumumab, Resistance, Therapy, Flex