Cancer stem cells: Radioresistance, prediction of radiotherapy outcome and specific targets for combined treatments

Publikation: Beitrag in FachzeitschriftÜbersichtsartikel (Review)BeigetragenBegutachtung

Abstract

Inactivation of cancer stem cells (CSCs) is of utmost importance for tumor cure after radiotherapy. An increasing body of evidence complies with a higher radioresistance of CSCs compared to the mass of tumor cells, supporting the use of CSC related biomarkers for prediction of radiotherapy outcome. Treatment individualization strategies for patient groups with vastly different risk of recurrence will most likely require application of more than one biomarker. Specifically, inclusion of established biomarkers like tumor size for primary radio(chemo)therapy or human papilloma virus (HPV) infection status in head and neck squamous cell carcinoma seems to be of very high relevance. The high heterogeneity of CSC subclones along with changes of the functional behavior of individual tumors under treatment underlines the importance of the selection of the optimal timepoint(s) of biomarker evaluation, but also provides a potential therapeutic target for combined treatment approaches with irradiation.

Details

OriginalspracheEnglisch
Seiten (von - bis)63-73
Seitenumfang11
FachzeitschriftAdvanced drug delivery reviews
Jahrgang109
PublikationsstatusVeröffentlicht - 15 Jan. 2017
Peer-Review-StatusJa

Externe IDs

PubMed 26877102
ORCID /0000-0003-1776-9556/work/171065825

Schlagworte

Ziele für nachhaltige Entwicklung

ASJC Scopus Sachgebiete

Schlagwörter

  • Biomarker, Cancer stem cells, Prediction, Prognosis, Radiotherapy