Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung


  • Esther Walton - , Bath Spa University (Autor:in)
  • Fabio Bernardoni - , Psychosoziale Medizin und Entwicklungsneurowissenschaften (Autor:in)
  • Victoria-Luise Batury - , Psychosoziale Medizin und Entwicklungsneurowissenschaften (Autor:in)
  • Klaas Bahnsen - , Psychosoziale Medizin und Entwicklungsneurowissenschaften (Autor:in)
  • Sara Larivière - , McGill University (Autor:in)
  • Giovanni Abbate-Daga - , University of Turin (Autor:in)
  • Susana Andres-Perpiña - , University of Barcelona (Autor:in)
  • Lasse Bang - , University of Oslo (Autor:in)
  • Amanda Bischoff-Grethe - , University of California at San Diego (Autor:in)
  • Samantha J Brooks - , Uppsala University (Autor:in)
  • Iain C Campbell - , King's College London (KCL) (Autor:in)
  • Giammarco Cascino - , University of Salerno (Autor:in)
  • Josefina Castro-Fornieles - , University of Barcelona (Autor:in)
  • Enrico Collantoni - , Università degli studi di Padova (Autor:in)
  • Federico D'Agata - , University of Turin (Autor:in)
  • Brigitte Dahmen - , RWTH Aachen University, Universitätsklinikum Aachen (Autor:in)
  • Unna N Danner - , Utrecht University (Autor:in)
  • Angela Favaro - , Università degli studi di Padova (Autor:in)
  • Jamie D Feusner - , University of Toronto (Autor:in)
  • Guido K W Frank - , University of California at San Diego (Autor:in)
  • Hans-Christoph Friederich - , Universitätsklinikum Heidelberg (Autor:in)
  • John L Graner - , Duke University (Autor:in)
  • Beate Herpertz-Dahlmann - , RWTH Aachen University, Universitätsklinikum Aachen (Autor:in)
  • Andreas Hess - , Friedrich-Alexander-Universität Erlangen-Nürnberg (Autor:in)
  • Stefanie Horndasch - , Universitätsklinikum der Friedrich-Alexander-Universität Erlangen-Nürnberg (Autor:in)
  • Allan S Kaplan - , University of Toronto (Autor:in)
  • Lisa-Katrin Kaufmann - , University of Zurich (Autor:in)
  • Walter H Kaye - , University of California at San Diego (Autor:in)
  • Sahib S Khalsa - , University of Tulsa (Autor:in)
  • Kevin S LaBar - , Duke University (Autor:in)
  • Luca Lavagnino - , University of Texas Health Science Center at Houston (Autor:in)
  • Luisa Lazaro - , University of Barcelona (Autor:in)
  • Renzo Manara - , Università degli studi di Padova (Autor:in)
  • Amy E Miles - , University of Toronto (Autor:in)
  • Gabriella F Milos - , University of Zurich (Autor:in)
  • Alessio Maria Monteleone - , Universita della Campania Luigi Vanvitelli (Autor:in)
  • Palmiero Monteleone - , University of Salerno (Autor:in)
  • Benson Mwangi - , University of Texas Health Science Center at Houston (Autor:in)
  • Owen O'Daly - , King's College London (KCL) (Autor:in)
  • Jose Pariente - , Magnetic Resonance Image Core Facility (Autor:in)
  • Julie Roesch - , Universitätsklinikum der Friedrich-Alexander-Universität Erlangen-Nürnberg (Autor:in)
  • Ulrike H Schmidt - , Tokyo Institute of Psychiatry, Technische Universität Dresden, King's College London (KCL) (Autor:in)
  • Jochen Seitz - , RWTH Aachen University, Universitätsklinikum Aachen (Autor:in)
  • Megan E Shott - , University of California at San Diego (Autor:in)
  • Joe J Simon - , Universitätsklinikum Heidelberg (Autor:in)
  • Paul A M Smeets - , Utrecht University (Autor:in)
  • Christian K Tamnes - , University of Oslo (Autor:in)
  • Elena Tenconi - , Università degli studi di Padova (Autor:in)
  • Sophia I Thomopoulos - , University of Southern California (Autor:in)
  • Annemarie A van Elburg - , Utrecht University (Autor:in)
  • Aristotle N Voineskos - , University of Toronto (Autor:in)
  • Georg G von Polier - , Universitätsklinikum Frankfurt (Autor:in)
  • Christina E Wierenga - , University of California at San Diego (Autor:in)
  • Nancy L Zucker - , Duke University (Autor:in)
  • Neda Jahanshad - , University of Southern California (Autor:in)
  • Joseph A King - , Psychosoziale Medizin und Entwicklungsneurowissenschaften, Technische Universität Dresden (Autor:in)
  • Paul M Thompson - , University of Southern California (Autor:in)
  • Laura A Berner - , Icahn School of Medicine at Mount Sinai (Autor:in)
  • Stefan Ehrlich - , Psychosoziale Medizin und Entwicklungsneurowissenschaften, Technische Universität Dresden (Autor:in)


BACKGROUND: The pattern of structural brain abnormalities in anorexia nervosa (AN) is still not well understood. While several studies report substantial deficits in gray matter volume and cortical thickness in acutely underweight patients, others find no differences, or even increases in patients compared with healthy control subjects. Recent weight regain before scanning may explain some of this heterogeneity. To clarify the extent, magnitude, and dependencies of gray matter changes in AN, we conducted a prospective, coordinated meta-analysis of multicenter neuroimaging data.

METHODS: We analyzed T1-weighted structural magnetic resonance imaging scans assessed with standardized methods from 685 female patients with AN and 963 female healthy control subjects across 22 sites worldwide. In addition to a case-control comparison, we conducted a 3-group analysis comparing healthy control subjects with acutely underweight AN patients (n = 466) and partially weight-restored patients in treatment (n = 251).

RESULTS: In AN, reductions in cortical thickness, subcortical volumes, and, to a lesser extent, cortical surface area were sizable (Cohen's d up to 0.95), widespread, and colocalized with hub regions. Highlighting the effects of undernutrition, these deficits were associated with lower body mass index in the AN sample and were less pronounced in partially weight-restored patients.

CONCLUSIONS: The effect sizes observed for cortical thickness deficits in acute AN are the largest of any psychiatric disorder investigated in the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium to date. These results confirm the importance of considering weight loss and renutrition in biomedical research on AN and underscore the importance of treatment engagement to prevent potentially long-lasting structural brain changes in this population.


Seiten (von - bis)730-738
FachzeitschriftBiological psychiatry
PublikationsstatusVeröffentlicht - 1 Nov. 2022

Externe IDs

Scopus 85136665057
ORCID /0000-0002-2864-5578/work/142233485
ORCID /0000-0003-2132-4445/work/142236359
ORCID /0000-0002-5112-405X/work/142242687
ORCID /0000-0002-5413-0359/work/142248936


Ziele für nachhaltige Entwicklung


  • Anorexia Nervosa/diagnostic imaging, Brain/diagnostic imaging, Cerebral Cortex/diagnostic imaging, Female, Humans, Magnetic Resonance Imaging/methods, Multicenter Studies as Topic, Prospective Studies, Thinness