Black Blood MRI in Suspected Large Artery Primary Angiitis of the Central Nervous System

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Thomas Pfefferkorn - , Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Jennifer Linn - , Klinikum der Ludwig-Maximilians-Universität (LMU) München, Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Maximilian Habs - , Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Christina Opherk - , Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Clemens Cyran - , Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Caroline Ottomeyer - , Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Andreas Straube - , Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Martin Dichgans - , Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Konstantin Nikolaou - , Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Tobias Saam - , Ludwig-Maximilians-Universität München (LMU) (Autor:in)

Abstract

OBJECTIVES: Single case reports suggest that black blood MRI (T1-weighted fat and blood suppressed sequences with and without contrast injection; BB-MRI) may visualize intracranial vessel wall contrast enhancement (CE) in primary angiitis of the central nervous system (PACNS). In this single-center observational pilot study we prospectively investigated the value of BB-MRI in the diagnosis of large artery PACNS. METHODS: Patients with suspected large artery PACNS received a standardized diagnostic program including BB-MRI. Vessel wall CE was graded (grade 0-2) by two experienced readers blinded to clinical data and correlated to the final diagnosis. RESULTS: Four of 12 included patients received a final diagnosis of PACNS. All of them showed moderate (grade 1) to strong (grade 2) vessel wall CE at the sites of stenosis. A moderate (grade 1) vessel wall CE grade was also observed in 6 of the remaining 8 patients in whom alternative diagnoses were made: arteriosclerotic disease (n= 4), intracranial dissection (n= 1), and Moyamoya disease (n= 1). CONCLUSIONS: Our pilot study demonstrates that vessel wall CE is a frequent finding in PACNS and its mimics. Larger trials will be necessary to evaluate the utility of BB-MRI in the diagnostic workup of PACNS.

Details

OriginalspracheEnglisch
Seiten (von - bis)379-383
Seitenumfang5
FachzeitschriftJournal of neuroimaging
Jahrgang23
Ausgabenummer3
PublikationsstatusVeröffentlicht - Juli 2013
Peer-Review-StatusJa
Extern publiziertJa

Externe IDs

PubMed 22928809

Schlagworte

Schlagwörter

  • Infarction, Inflammation, MRI, Vasculitis