Bacterial (intramembrane-sensing) histidine kinases: signal transfer rather than stimulus perception

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

Abstract

Most membrane-anchored histidine kinases (HKs) of bacterial two-component systems (2CSs) contain an extracellular input domain that is thought to be responsible for sensing an environmental cue. By contrast, intramembrane-sensing HKs (IM-HKs) lack a sensory domain and cannot perceive their stimuli directly. Instead, an N-terminal signal transfer region, consisting solely of two transmembrane helices, presumably connects the IM-HKs with accessory membrane proteins that function as the true sensors. This intermolecular signal transfer, in combination with intramolecular signal conversion, provides HKs with versatile signaling relays to connect, integrate, and amplify external signals from different sensory inputs ultimately to modulate the activity of the corresponding kinase domain.

Details

OriginalspracheEnglisch
Seiten (von - bis)559-65
Seitenumfang7
FachzeitschriftTrends in microbiology
Jahrgang22
Ausgabenummer10
PublikationsstatusVeröffentlicht - Okt. 2014
Peer-Review-StatusJa

Externe IDs

PubMed 24947190
Scopus 84908510408

Schlagworte

Schlagwörter

  • Bacteria/enzymology, Bacterial Proteins/genetics, Histidine Kinase, Protein Kinases/metabolism, Signal Transduction