Associations of cortical thickness and cognition in patients with schizophrenia and healthy controls

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Stefan Ehrlich - , Klinik und Poliklinik für Kinder- und Jugendpsychiatrie, Harvard Medical School (HMS), Massachusetts General Hospital, Universitätsklinikum Carl Gustav Carus Dresden, Athinoula A. Martinos Center for Biomedical Imaging (Autor:in)
  • Stefan Brauns - , Massachusetts General Hospital (Autor:in)
  • Anastasia Yendiki - , Massachusetts General Hospital (Autor:in)
  • Beng Choon Ho - , University of Iowa (Autor:in)
  • Vince Calhoun - , The Mind Research Network, University of New Mexico (Autor:in)
  • S. Charles Schulz - , University of Minnesota System (Autor:in)
  • Randy L. Gollub - , Massachusetts General Hospital (Autor:in)
  • Scott R. Sponheim - , University of Minnesota System, VA Medical Center (Autor:in)

Abstract

Previous studies have found varying relationships between cognitive functioning and brain volumes in patients with schizophrenia. However, cortical thickness may more closely reflect cytoarchitectural characteristics than gray matter density or volume estimates. Here, we aimed to compare associations between regional variation in cortical thickness and executive functions, memory, as well as verbal and spatial processing in patients with schizophrenia and healthy controls (HCs). We obtained magnetic resonance imaging and neuropsychological data for 131 patients and 138 matched controls. Automated cortical pattern matching methods allowed testing for associations with cortical thickness estimated as the shortest distance between the gray/white matter border and the pial surface at thousands of points across the entire cortical surface. Two independent measures of working memory showed robust associations with cortical thickness in lateral prefrontal cortex in HCs, whereas patients exhibited associations between working memory and cortical thickness in the right middle and superior temporal lobe. This study provides additional evidence for a disrupted structure-function relationship in schizophrenia. In line with the prefrontal inefficiency hypothesis, schizophrenia patients may engage a larger compensatory network of brain regions other than frontal cortex to recall and manipulate verbal material in working memory.

Details

OriginalspracheEnglisch
Seiten (von - bis)1050-1062
Seitenumfang13
FachzeitschriftSchizophrenia bulletin
Jahrgang38
Ausgabenummer5
PublikationsstatusVeröffentlicht - Sept. 2012
Peer-Review-StatusJa

Externe IDs

PubMed 21436318
ORCID /0000-0003-2132-4445/work/160950895

Schlagworte

Ziele für nachhaltige Entwicklung

Schlagwörter

  • cognitive dysfunction, gray matter thickness, structural MRI, working memory