Association of Tumor Necrosis Factor-α Inhibitors with Incident Dementia: Analysis Based on Population-Based Cohort Studies

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

Abstract

Background and Objective: Preliminary evidence suggests a possible preventive effect of tumor necrosis factor-α inhibitors (TNFi) on incident dementia. The objective of the analysis was to investigate the association between TNFi and the risk of incident dementia in a population undergoing treatment for rheumatological disorders. Methods: We followed patients aged ≥ 65 years with dementia and rheumatological conditions in two cohort studies, DANBIO (N = 21,538), a Danish clinical database, and AOK PLUS (N = 7112), a German health insurance database. We defined incident dementia using diagnostic codes and/or medication use and used Cox regression to compare the associations of TNFi with other rheumatological therapies on the risk of dementia. To ensure that the patients were receiving long-term medication, we included patients with rheumatic diseases and systemic therapies. Results: We observed similar trends towards a lower risk of dementia associated with TNFi versus other anti-inflammatory agents in both cohorts (hazard ratios were 0.92 [95% confidence interval 0.76, 1.10] in DANBIO and 0.89 [95% confidence interval 0.63, 1.24] in AOK PLUS, respectively). Conclusions: Tumor necrosis factor-α inhibitors may decrease the risk of incident dementia although the association did not reach statistical significance in this analysis. Further research, ideally with randomization, is needed to gauge the potential of repurposing TNFi for dementia prevention and/or treatment.

Details

OriginalspracheEnglisch
Seiten (von - bis)423-430
Seitenumfang8
Fachzeitschrift Drugs & aging : evaluations of age-related changes in drug disposition and drug therapy in the elderly
Jahrgang41
Ausgabenummer5
PublikationsstatusVeröffentlicht - 12 Apr. 2024
Peer-Review-StatusJa

Externe IDs

Scopus 85190111504
PubMed 38609734
Mendeley 2d5d8e81-7bdd-3829-aefa-eaffb0c41477

Schlagworte

Schlagwörter

  • Tumor Necrosis Factor-alpha/antagonists & inhibitors, Rheumatic Diseases/drug therapy, Denmark/epidemiology, Humans, Dementia/epidemiology, Aged, 80 and over, Male, Female, Aged, Cohort Studies, Incidence