In today's data-driven world, economy and research depend on the analysis of empirical datasets to guide decision making. These applications often encompass a rich variety of data types and special purpose processing models. We believe, the database system of the future will integrate flexible processing and storage of a variety of data types in a scalable and integrated end-to-end solution. In this paper, we propose a database system architecture that is designed from the core to support these goals. In the discussion we will especially focus on the multi-domain programming concept of the proposed architecture that exploits domain specific knowledge to guide compiler based optimization.