Apoptotic cell death in disease-Current understanding of the NCCD 2023

Publikation: Beitrag in FachzeitschriftÜbersichtsartikel (Review)BeigetragenBegutachtung


  • Italian Institute for Genomic Medicine (IIGM)
  • Karolinska Institutet
  • Weill Cornell Medical College in Qatar
  • Icahn School of Medicine at Mount Sinai
  • University of Texas Southwestern Medical Center
  • Christian-Albrechts-Universität zu Kiel (CAU)
  • University of Rome Tor Vergata
  • Department of Cellular and Molecular Medicine
  • Thomas Jefferson University
  • Universita della Campania Luigi Vanvitelli
  • University of Konstanz
  • Sunnybrook Health Science Centre
  • Hebrew University of Jerusalem
  • Weizmann Institute of Science
  • University of Massachusetts Medical School
  • Fox Chase Cancer Center
  • Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE)
  • Nazarbayev University
  • Louisiana State University Health Sciences Center
  • Friedrich-Alexander-Universität Erlangen-Nürnberg
  • VIB-UGent Center for Inflammation Research
  • University of Connecticut
  • Roswell Park Comprehensive Cancer Center
  • Jill Roberts Institute for Research in Inflammatory Bowel Disease
  • IRCSS Regina Elena National Cancer Institute
  • Albert-Ludwigs-Universität Freiburg
  • National Institutes of Health (NIH)
  • Centro de Investigaciones Biologicas Margarita Salas
  • Université Paris-Saclay
  • Université de Lausanne
  • Technical University of Denmark
  • University of Texas at Austin
  • Queen Mary University of London
  • University of Hawai'i at Mānoa
  • Technische Universität Graz
  • Center for Autophagy
  • Duke University
  • Shanghai Jiao Tong University
  • Nankai University
  • Shenzhen Institute of Advanced Technology (SIAT)
  • Memorial Sloan-Kettering Cancer Center


Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.


Seiten (von - bis)1097-1154
FachzeitschriftCell death and differentiation
PublikationsstatusVeröffentlicht - Mai 2023

Externe IDs

PubMedCentral PMC10130819
Scopus 85153609153
ORCID /0000-0001-6874-0548/work/148143851
ORCID /0000-0001-6287-9725/work/148145950


Ziele für nachhaltige Entwicklung


  • Animals, Humans, Apoptosis/genetics, Cell Death, Caspases/genetics, Carcinogenesis, Mammals/metabolism