Normative specifications and guidelines for the supplementary use of sensorbased monitoring in the assessment of road bridges are currently insufficient. This leads to heterogeneous approaches in measurement-based recalculations. In the research project ANYTWIN, standardized measurement and analysis concepts are being developed for selected structural safety verifications. Engineers will benefit from recommendations for actions that can be applied to structures with similar issues. To ensure sustainable and interoperable usage, concepts for integrating structural safety verifications into Digital Twins are created. This will enable information to be interoperably utilized across generations. The automated and standardized integration and analysis of measurement data prospectively establish a crucial core functionality of Digital Twins in infrastructure. The concepts are validated with extensive data from the model bridge of the research project IDA-KI and the Digital Twin of the Köhlbrand Bridge. The ANYTWIN research project commenced in September 2023 and is funded for three years by the Federal Ministry of Digital and Transport (BMDV). Approaches and initial results are presented in this paper.