Antimicrobial Brushes on Titanium via “Grafting to” Using Phosphonic Acid/Pyridinium Containing Block Copolymers

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung


  • Rafael Methling - , Paderborn University (Autor:in)
  • Oliver Dückmann - , Paderborn University (Autor:in)
  • Frank Simon - , Leibniz Institute of Polymer Research Dresden (Autor:in)
  • Cornelia Wolf-Brandstetter - , Professur für Biomaterialien (Autor:in)
  • Dirk Kuckling - , Paderborn University (Autor:in)


Coating medical implants with antibacterial polymers may prevent postoperative infections which are a common issue for conventional titanium implants and can even lead to implant failure. Easily applicable diblock copolymers are presented that form polymer brushes via “grafting to” mechanism on titanium and equip the modified material with antibacterial properties. The polymers carry quaternized pyridinium units to combat bacteria and phosphonic acid groups which allow the linear chains to be anchored to metal surfaces in a convenient coating process. The polymers are synthesized via reversible-addition-fragmentation-chain-transfer (RAFT) polymerization and postmodifications and are characterized using NMR spectroscopy and SEC. Low grafting densities are a major drawback of the “grafting to” approach compared to “grafting from”. Thus, the number of phosphonic acid groups in the anchor block are varied to investigate and optimize the surface binding. Modified titanium surfaces are examined regarding their composition, wetting behavior, streaming potential, and coating stability. Evaluation of the antimicrobial properties revealed reduced bacterial adhesion and biofilm formation for certain polymers, albeit the cell biocompatibility against human gingival fibroblasts is also impaired. The presented findings show the potential of easy-to-apply polymer coatings and aid in designing next-generation implant surface modifications.


Seiten (von - bis)2200665
FachzeitschriftMacromolecular Materials and Engineering
PublikationsstatusVeröffentlicht - Aug. 2023

Externe IDs

Scopus 85148453324
ORCID /0000-0001-9509-6145/work/142257649
WOS 000937656200001
Mendeley 002d2f4f-ca75-38a9-ab3d-c18f995654dc


Forschungsprofillinien der TU Dresden

DFG-Fachsystematik nach Fachkollegium

Fächergruppen, Lehr- und Forschungsbereiche, Fachgebiete nach Destatis


  • Antimicrobial polymers, Antimicrobial surfaces, Grafting to, Polymer brushes