A chemically assisted top-down method for the synthesis of MOF-nanoplates was developed applying amine based delamination agents. Applied on a well described model structure, the layered MOF Cu₂(bdc)₂(DMF)₂ (bdc-1,4-benzenedicarboxylate), two different strategies of amine assisted delamination turned out to be successful to obtain nanoplates. Particles with thicknesses of around 70 nm were obtained by direct delamination of crystals using octylamine. The surfactant (polyvinylpyrrolidone) assisted synthesis combined with a post-synthetic amine delamination step enabled a further reduction of the thickness of the MOF nanoplates down to 4-14 nm.