Alcohol-induced deficits in reactive control of response selection and inhibition are counteracted by a seemingly paradox increase in proactive control

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung



High-dose alcohol intoxication reduces cognitive control, including inhibition. Although inhibition deficits may contribute to the behavioral deficits commonly observed in alcohol use disorder (AUD), many questions about potentially modulating factors have remained unanswered. We examined the effects of experimentally induced high-dose alcohol intoxication (~ 1.1 ‰) on the interplay between controlled vs. automatic response selection and inhibition in healthy young men. A holistic EEG-based theta activity analysis that considered both reactive control during task performance and preceding proactive control processes was run. It revealed a previously unknown seesaw relationship, with decreased reactive control, but paradoxically increased proactive control. Most importantly, alcohol-induced increases in proactive occipital theta band power were associated with reductions in negative alcohol effects on reactive control processes associated with decreased activity in the SMA and medial frontal cortex. Our findings demonstrate that research should not solely focus on immediate effects during task performance. Aside from differential neurobiochemical and neuroanatomical effects of alcohol, it is also conceivable that proactive control may have been recruited in a (secondary) response to compensate for alcohol-induced impairments in reactive control. Against this background, it could be promising to investigate changes in such compensatory mechanisms in pronounced alcohol-associated inhibition deficits, like in AUD patients.


FachzeitschriftScientific reports
PublikationsstatusVeröffentlicht - Dez. 2023

Externe IDs

PubMed 36658291
ORCID /0000-0002-7155-1067/work/143957963
WOS 000988257400042
ORCID /0000-0002-2989-9561/work/146788761


Ziele für nachhaltige Entwicklung

ASJC Scopus Sachgebiete


  • Addiction, Areas, Binge drinking, Dependence, Interference, Model, Noninvasive brain-stimulation, Stimulus, System, Theta oscillations, Alcoholism, Humans, Alcoholic Intoxication/psychology, Male, Alcohol Drinking, Frontal Lobe, Ethanol/toxicity