Optical manipulation and tomographic imaging play critical roles in biomedical applications, however, applying these technologies to hard-to-reach regions remains challenging. We introduce a series of innovative AI-driven methods designed to facilitate both high-fidelity light field control and image reconstruction through a multicore fiber-optic system. Our approach enables precise, controlled rotation of human cancer cells around all three axes, enabling 3D tomographic reconstructions of these cells with isotropic resolution. The integration of these advanced optical and computational techniques culminates in a powerful optical fiber probe, capable of sophisticated optical manipulation and tomographic imaging, offering new perspectives for optical manipulation and its applications.