AHR agonistic effects of 6-PN contribute to potential beneficial effects of Hops extract
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
- Instituto de Salud y Ambiente del Litoral (ISAL)
Abstract
Hops (Humulus lupulus) is used as an alternative to hormone replacement therapy due to the phytoestrogen, 8-prenylnaringenin (8-PN). To examine the potential risks/benefits of hops extract and its compounds (8-PN and 6-prenylnaringenin, 6-PN), we aimed to evaluate the estrogen receptor α (ERα) and aryl hydrocarbon receptor (AHR) signaling pathways in human endometrial cancer cells. Hops extract, 8-PN and 6-PN showed estrogenic activity. Hops extract and 6-PN activated both ERα and AHR pathways. 6-PN increased the expression of the tumor suppressor gene (AHRR), and that of genes involved in the estrogen metabolism (CYP1A1, CYP1B1). Although 6-PN might activate the detoxification and genotoxic pathways of estrogen metabolism, hops extract as a whole only modulated the genotoxic pathway by an up-regulation of CYP1B1 mRNA expression. These data demonstrate the relevant role of 6-PN contained in the hops extract as potential modulator of estrogen metabolism due to its ERα and AHR agonist activity.
Details
Originalsprache | Englisch |
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Aufsatznummer | 111540 |
Fachzeitschrift | Molecular and cellular endocrinology |
Jahrgang | 543 |
Publikationsstatus | Veröffentlicht - 1 März 2022 |
Peer-Review-Status | Ja |
Externe IDs
Scopus | 85122071981 |
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unpaywall | 10.1016/j.mce.2021.111540 |
ORCID | /0000-0001-5397-7972/work/142245259 |
Schlagworte
Ziele für nachhaltige Entwicklung
ASJC Scopus Sachgebiete
Schlagwörter
- Aryl hydrocarbon receptor, CYP1A1, CYP1B1, Estrogen receptor, Hops, Ishikawa cells