The nexus concept has considerably matured during the past decade. Numerous literature reviews have significantly contributed to taking stock of the advancements in knowledge and tool development to improve science-policy support on highly connected and interdependent resources. However, literature reviews often focus on specific sector-based nexus concepts (such as water-energy-food nexus) and analyses (such as environmental assessment, technical tools, or the management and policy dimension). Therefore, a comprehensive understanding of the actual nexus and the resources it builds upon still needs to be improved. This paper aims to test the validity of the nexus construct for research and practice. Based on a systematic review of reviews, including 62 nexus-related review papers and subsequent consultation of some sixty nexus experts, we suggest a robust but flexible approach to advancing the Resource Nexus for research and practice. In doing so, the knowledge provided by nexus research may provide more substantial support to decision-makers when designing and implementing policies for the sustainable management of environmental resources.