The relationships between risk behaviors and factors representing multiple ecological layers are examined among a sample of youth in grades seven through 12 (n = 2,701). Our primary interest is in the relationship between structured time-use as a protective factor and youth risk behavior patterns. Two other layers of protective factors are also examined, those dealing with interpersonal connections and with self-system characteristics. Concomitant demographic factors in the study are age, ethnicity, gender, and socioeconomic status. Stepwise multiple regression analysis reveals that less risk behavior is associated with greater attachment to school, greater school success, closer relationships with parents, and greater participation in structured time-use; significant predictors of more risk behavior are being older, being male, and having one good friend. Implications for professional practice include employing a comprehensive, ecological approach to prevention and intervention, and enacting social support initiatives at multiple levels.